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If the discomfort is bothersome, over-the-counter pain relievers such as acetaminophen or ibuprofen may helpprovided you do not have any contraindications to these medications

They also introduced mutations that optimized the enzymes overall kinetics with the goal of driving the gluten peptide levels below the threshold for toxicity, which is estimated at 50 milligrams per day, and doing so within a physiologically relevant timeframe (7)

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